Internal User

30 DAYS

Training Module

ADVANCE BIOINFORMATICS

(ABI)

Basic Bioinformatics

• Introduction to Bioinformatics & NCBI.

• Study of various file formats.

• Sequence retrieval from databases.

• Alignment of sequences using BLAST.

• Primer designing for a given sequence.

 

Comparative tools

• Pairwise alignment using EMBOSS.

• Multiple Sequence Alignment using various tools.

• Phylogeny and Cladogram Analysis.

• Complete genome comparison.

• Analysis of percentage divergence between species.

• Phylogenetic tree construction using various software’s

 

Prediction tools

• Gene prediction tools.

• Secondary structure prediction tool.

• Ligand property prediction tool.

• Toxicity and ADME properties prediction tool.

• ORF finding tool.

• Prediction of potential cleavage sites by ExPasy web tool.

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Drug Designing approach

• Active site prediction of target protein.

• Retrieval of small Molecules from zinc Database/Pubchem

• Drug linkliness of compound

• Screening of ligands on basis of Lipinski rule of 5

• Inter conversion of various file Conversion using software

• Homology modeling for structure of unknown proteins

 

Docking of Protein and ligand

• Protein preparation and docking in Autodock Vina

• Docking on HEX server

• Docking on PyRex

• Poses analysis using PyMol

• Interaction of Protein-ligand residues in the active site

 

Requirements:

• Laptop is a must for this training.

• Link for Software will either be shared with you or you will have to download the software during training, We will let you know that in advance.

15 DAYS

Training Module

BASIC BIOINFORMATICS

(BBI)

• Introduction to Bioinformatics & NCBI

• Study of various file formats

• Sequence retrieval from databases

• Alignment of sequences using BLAST

• Primer designing for a given sequence

• Pairwise alignment using EMBOSS

• Multiple Sequence Alignment using various tools

• Phylogeny and Cladogram Analysis

• Complete genome comparison

• Analysis of percentage divergence between species

• Phylogenetic tree construction using various software’s

• Gene prediction tools

• Secondary structure prediction tool

• Ligand property prediction tool

• Toxicity and ADME properties prediction tool

• ORF finding tool

• Prediction of potential cleavage sites by ExPasy web tool

• Active site prediction of target protein.

• Retrieval of small Molecules from zinc Database/Pubchem

• Drug linkliness of compound

​

Requirements:

• Laptop is a must for this training.

• Link for Software will either be shared with you or you will have to download the software during training, We will let you know that in advance.